H2N2V1, Main, Exploration, bibRecord, 001F22

A common neutralizing epitope conserved between the hemagglutinins of influenza A virus H1 and H2 strains

Identifieur interne : 001F22 ( Main/Exploration ); précédent : 001F21; suivant : 001F23

A common neutralizing epitope conserved between the hemagglutinins of influenza A virus H1 and H2 strains

Auteurs : Y. Okuno [Japon] ; Y. Isegawa ; F. Sasao ; S. Ueda

Source :

Journal of virology [ 0022-538X ] ; 1993.

RBID : Pascal:93-0479202

Descripteurs français

KwdFr :
- Animaux, Anticorps antiviraux (immunologie), Anticorps monoclonaux (immunologie), Antigènes viraux (génétique), Antigènes viraux (immunologie), Cellules cultivées, Conformation des protéines, Données de séquences moléculaires, Fusion cellulaire, Glycoprotéine hémagglutinine du virus influenza, Hémagglutinines virales (génétique), Hémagglutinines virales (immunologie), Modèles moléculaires, Orthomyxoviridae (génétique), Orthomyxoviridae (immunologie), Souris, Souris de lignée BALB C, Spécificité d'espèce, Spécificité des anticorps, Séquence conservée, Séquence d'acides aminés, Séquence nucléotidique, Tests de neutralisation, Épitopes.
MESH :
- génétique : Antigènes viraux, Hémagglutinines virales, Orthomyxoviridae.
- immunologie : Anticorps antiviraux, Anticorps monoclonaux, Antigènes viraux, Hémagglutinines virales, Orthomyxoviridae.
Pascal (Inist)
- Animaux, Cellules cultivées, Conformation des protéines, Données de séquences moléculaires, Fusion cellulaire, Glycoprotéine hémagglutinine du virus influenza, Influenzavirus A, Hémagglutinine, Glycoprotéine, Déterminant antigénique, Anticorps monoclonal, Hybridome, Modèles moléculaires, Neutralisation, Fusion cellulaire, Cellule infectée, Etude comparative, Souche, Souris, Souris de lignée BALB C, Spécificité d'espèce, Spécificité des anticorps, Séquence aminoacide, Séquence conservée, Séquence d'acides aminés, Séquence nucléotidique, Tests de neutralisation, Épitopes.

English descriptors

KwdEn :
- Amino Acid Sequence, Aminoacid sequence, Animals, Antibodies, Monoclonal (immunology), Antibodies, Viral (immunology), Antibody Specificity, Antigenic determinant, Antigens, Viral (genetics), Antigens, Viral (immunology), Base Sequence, Cell Fusion, Cell fusion, Cells, Cultured, Comparative study, Conserved Sequence, Epitopes, Glycoproteins, Hemagglutinin, Hemagglutinin Glycoproteins, Influenza Virus, Hemagglutinins, Viral (genetics), Hemagglutinins, Viral (immunology), Hybridoma, Infected cell, Influenzavirus A, Mice, Mice, Inbred BALB C, Models, Molecular, Molecular Sequence Data, Monoclonal antibody, Neutralization, Neutralization Tests, Orthomyxoviridae (genetics), Orthomyxoviridae (immunology), Protein Conformation, Species Specificity, Strain.
MESH :
- chemical , genetics : Antigens, Viral, Hemagglutinins, Viral.
- chemical , immunology : Antibodies, Monoclonal, Antibodies, Viral, Antigens, Viral, Hemagglutinins, Viral.
- genetics : Orthomyxoviridae.
- immunology : Orthomyxoviridae.
- Amino Acid Sequence, Animals, Antibody Specificity, Base Sequence, Cell Fusion, Cells, Cultured, Conserved Sequence, Epitopes, Hemagglutinin Glycoproteins, Influenza Virus, Mice, Mice, Inbred BALB C, Models, Molecular, Molecular Sequence Data, Neutralization Tests, Protein Conformation, Species Specificity.

Abstract

When mice were immunized with the A/Okuda/57 (H2N2) strain of influenza virus, a unique monoclonal antibody designated C179 was obtained. Although C179 was confirmed to recognize the hemagglutinin (HA) glycoprotein by immunoprecipitation assays, it did not show hemagglutination inhibition activity to any of the strains of the three subtypes of influenza A virus. However, it neutralized all of the H1 and H2 strains but not the H3 strains. Moreover, it inhibited polykaryon formation induced by the H1 and H2 strains but not by the H3 strains. Two antigenic variants against C179 were obtained, and nucleotide sequence analysis revealed that amino acid sequences, from 318 to 322 of HA, and from 47 to 58 of HA₂, conserved among H1 and H2 strains were responsible for the recognition of C179

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC237575

Affiliations:

Japon

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">A common neutralizing epitope conserved between the hemagglutinins of influenza A virus H1 and H2 strains</title>
<author><name sortKey="Okuno, Y" sort="Okuno, Y" uniqKey="Okuno Y" first="Y." last="Okuno">Y. Okuno</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Osaka univ., res. inst. microbial diseases, dep. preventive medicine</s1>
<s2>Suita, Osaka 565</s2>
<s3>JPN</s3>
</inist:fA14>
<country>Japon</country>
<wicri:noRegion>Suita, Osaka 565</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Isegawa, Y" sort="Isegawa, Y" uniqKey="Isegawa Y" first="Y." last="Isegawa">Y. Isegawa</name>
</author>
<author><name sortKey="Sasao, F" sort="Sasao, F" uniqKey="Sasao F" first="F." last="Sasao">F. Sasao</name>
</author>
<author><name sortKey="Ueda, S" sort="Ueda, S" uniqKey="Ueda S" first="S." last="Ueda">S. Ueda</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">93-0479202</idno>
<date when="1993">1993</date>
<idno type="stanalyst">PASCAL 93-0479202 INIST</idno>
<idno type="RBID">Pascal:93-0479202</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000101</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000113</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000103</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000103</idno>
<idno type="wicri:doubleKey">0022-538X:1993:Okuno Y:a:common:neutralizing</idno>
<idno type="wicri:Area/Main/Merge">002013</idno>
<idno type="wicri:source">PMC</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC237575</idno>
<idno type="RBID">PMC:237575</idno>
<idno type="wicri:Area/Pmc/Corpus">000413</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000413</idno>
<idno type="wicri:Area/Pmc/Curation">000413</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000413</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000D09</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000D09</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:7682624</idno>
<idno type="wicri:Area/PubMed/Corpus">000426</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000426</idno>
<idno type="wicri:Area/PubMed/Curation">000426</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000426</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000387</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000387</idno>
<idno type="wicri:Area/Ncbi/Merge">001291</idno>
<idno type="wicri:Area/Ncbi/Curation">001291</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001291</idno>
<idno type="wicri:doubleKey">0022-538X:1993:Okuno Y:a:common:neutralizing</idno>
<idno type="wicri:Area/Main/Merge">001F45</idno>
<idno type="wicri:Area/Main/Curation">001F22</idno>
<idno type="wicri:Area/Main/Exploration">001F22</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">A common neutralizing epitope conserved between the hemagglutinins of influenza A virus H1 and H2 strains</title>
<author><name sortKey="Okuno, Y" sort="Okuno, Y" uniqKey="Okuno Y" first="Y." last="Okuno">Y. Okuno</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Osaka univ., res. inst. microbial diseases, dep. preventive medicine</s1>
<s2>Suita, Osaka 565</s2>
<s3>JPN</s3>
</inist:fA14>
<country>Japon</country>
<wicri:noRegion>Suita, Osaka 565</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Isegawa, Y" sort="Isegawa, Y" uniqKey="Isegawa Y" first="Y." last="Isegawa">Y. Isegawa</name>
</author>
<author><name sortKey="Sasao, F" sort="Sasao, F" uniqKey="Sasao F" first="F." last="Sasao">F. Sasao</name>
</author>
<author><name sortKey="Ueda, S" sort="Ueda, S" uniqKey="Ueda S" first="S." last="Ueda">S. Ueda</name>
</author>
</analytic>
<series><title level="j" type="main">Journal of virology</title>
<title level="j" type="abbreviated">J. virol.</title>
<idno type="ISSN">0022-538X</idno>
<imprint><date when="1993">1993</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Journal of virology</title>
<title level="j" type="abbreviated">J. virol.</title>
<idno type="ISSN">0022-538X</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Aminoacid sequence</term>
<term>Animals</term>
<term>Antibodies, Monoclonal (immunology)</term>
<term>Antibodies, Viral (immunology)</term>
<term>Antibody Specificity</term>
<term>Antigenic determinant</term>
<term>Antigens, Viral (genetics)</term>
<term>Antigens, Viral (immunology)</term>
<term>Base Sequence</term>
<term>Cell Fusion</term>
<term>Cell fusion</term>
<term>Cells, Cultured</term>
<term>Comparative study</term>
<term>Conserved Sequence</term>
<term>Epitopes</term>
<term>Glycoproteins</term>
<term>Hemagglutinin</term>
<term>Hemagglutinin Glycoproteins, Influenza Virus</term>
<term>Hemagglutinins, Viral (genetics)</term>
<term>Hemagglutinins, Viral (immunology)</term>
<term>Hybridoma</term>
<term>Infected cell</term>
<term>Influenzavirus A</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Models, Molecular</term>
<term>Molecular Sequence Data</term>
<term>Monoclonal antibody</term>
<term>Neutralization</term>
<term>Neutralization Tests</term>
<term>Orthomyxoviridae (genetics)</term>
<term>Orthomyxoviridae (immunology)</term>
<term>Protein Conformation</term>
<term>Species Specificity</term>
<term>Strain</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Anticorps antiviraux (immunologie)</term>
<term>Anticorps monoclonaux (immunologie)</term>
<term>Antigènes viraux (génétique)</term>
<term>Antigènes viraux (immunologie)</term>
<term>Cellules cultivées</term>
<term>Conformation des protéines</term>
<term>Données de séquences moléculaires</term>
<term>Fusion cellulaire</term>
<term>Glycoprotéine hémagglutinine du virus influenza</term>
<term>Hémagglutinines virales (génétique)</term>
<term>Hémagglutinines virales (immunologie)</term>
<term>Modèles moléculaires</term>
<term>Orthomyxoviridae (génétique)</term>
<term>Orthomyxoviridae (immunologie)</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
<term>Spécificité d'espèce</term>
<term>Spécificité des anticorps</term>
<term>Séquence conservée</term>
<term>Séquence d'acides aminés</term>
<term>Séquence nucléotidique</term>
<term>Tests de neutralisation</term>
<term>Épitopes</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Antigens, Viral</term>
<term>Hemagglutinins, Viral</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Monoclonal</term>
<term>Antibodies, Viral</term>
<term>Antigens, Viral</term>
<term>Hemagglutinins, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Orthomyxoviridae</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Antigènes viraux</term>
<term>Hémagglutinines virales</term>
<term>Orthomyxoviridae</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps antiviraux</term>
<term>Anticorps monoclonaux</term>
<term>Antigènes viraux</term>
<term>Hémagglutinines virales</term>
<term>Orthomyxoviridae</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Orthomyxoviridae</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Animals</term>
<term>Antibody Specificity</term>
<term>Base Sequence</term>
<term>Cell Fusion</term>
<term>Cells, Cultured</term>
<term>Conserved Sequence</term>
<term>Epitopes</term>
<term>Hemagglutinin Glycoproteins, Influenza Virus</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Models, Molecular</term>
<term>Molecular Sequence Data</term>
<term>Neutralization Tests</term>
<term>Protein Conformation</term>
<term>Species Specificity</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Animaux</term>
<term>Cellules cultivées</term>
<term>Conformation des protéines</term>
<term>Données de séquences moléculaires</term>
<term>Fusion cellulaire</term>
<term>Glycoprotéine hémagglutinine du virus influenza</term>
<term>Influenzavirus A</term>
<term>Hémagglutinine</term>
<term>Glycoprotéine</term>
<term>Déterminant antigénique</term>
<term>Anticorps monoclonal</term>
<term>Hybridome</term>
<term>Modèles moléculaires</term>
<term>Neutralisation</term>
<term>Fusion cellulaire</term>
<term>Cellule infectée</term>
<term>Etude comparative</term>
<term>Souche</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
<term>Spécificité d'espèce</term>
<term>Spécificité des anticorps</term>
<term>Séquence aminoacide</term>
<term>Séquence conservée</term>
<term>Séquence d'acides aminés</term>
<term>Séquence nucléotidique</term>
<term>Tests de neutralisation</term>
<term>Épitopes</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">When mice were immunized with the A/Okuda/57 (H2N2) strain of influenza virus, a unique monoclonal antibody designated C179 was obtained. Although C179 was confirmed to recognize the hemagglutinin (HA) glycoprotein by immunoprecipitation assays, it did not show hemagglutination inhibition activity to any of the strains of the three subtypes of influenza A virus. However, it neutralized all of the H1 and H2 strains but not the H3 strains. Moreover, it inhibited polykaryon formation induced by the H1 and H2 strains but not by the H3 strains. Two antigenic variants against C179 were obtained, and nucleotide sequence analysis revealed that amino acid sequences, from 318 to 322 of HA, and from 47 to 58 of HA<sub>2</sub>
, conserved among H1 and H2 strains were responsible for the recognition of C179</div>
</front>
</TEI>
<affiliations><list><country><li>Japon</li>
</country>
</list>
<tree><noCountry><name sortKey="Isegawa, Y" sort="Isegawa, Y" uniqKey="Isegawa Y" first="Y." last="Isegawa">Y. Isegawa</name>
<name sortKey="Sasao, F" sort="Sasao, F" uniqKey="Sasao F" first="F." last="Sasao">F. Sasao</name>
<name sortKey="Ueda, S" sort="Ueda, S" uniqKey="Ueda S" first="S." last="Ueda">S. Ueda</name>
</noCountry>
<country name="Japon"><noRegion><name sortKey="Okuno, Y" sort="Okuno, Y" uniqKey="Okuno Y" first="Y." last="Okuno">Y. Okuno</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001F22 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001F22 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    H2N2V1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     Pascal:93-0479202
   |texte=   A common neutralizing epitope conserved between the hemagglutinins of influenza A virus H1 and H2 strains
}}

This area was generated with Dilib version V0.6.33.
Data generation: Tue Apr 14 19:59:40 2020. Site generation: Thu Mar 25 15:38:26 2021

Serveur d'exploration H2N2

A common neutralizing epitope conserved between the hemagglutinins of influenza A virus H1 and H2 strains

A common neutralizing epitope conserved between the hemagglutinins of influenza A virus H1 and H2 strains

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Serveur d'exploration H2N2
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.